FDA-approved·Recombinant growth hormone
Somatropin (HGH)
aka Recombinant human growth hormone, rHGH
Education only. Many compounds discussed are research chemicals not approved for human use in the US. This is not medical advice — consult a licensed physician.
What it is
FDA-approved recombinant human growth hormone. Approved for pediatric GH deficiency, adult GH deficiency, and several wasting conditions. Off-label use for anti-aging is common but not FDA-supported.
How it works
Identical to endogenous GH. Binds GH receptors, triggers IGF-1 release from liver, drives anabolic effects on muscle, bone, and metabolism.
What the research says
Decades of clinical use. Adult GH deficiency: improved body composition, lipids. Anti-aging use: high risk of insulin resistance, edema, joint pain.
Sources: NEJM Rudman 1990 · FDA Genotropin label
Common dosing ranges
- Range
- Adult deficiency: 0.15–0.3 mg/day. Anti-aging protocols: 1–2 IU/day.
- Frequency
- Daily, subQ
- Duration
- Long-term per medical indication
Sources: FDA Genotropin label
Administration
SubQ
Half-life
~3 hours
Side effects
Common
- Edema
- Carpal tunnel
- Joint pain
- Insulin resistance
Serious / theoretical
- T2D
- Increased mortality (if elevated long-term per Rudman follow-up)
- Cancer growth concerns
Sources: FDA label