Research only·Russian-developed neuropeptide

Semax

aka ACTH (4-10) Pro-Gly-Pro analog

Education only. Many compounds discussed are research chemicals not approved for human use in the US. This is not medical advice — consult a licensed physician.

What it is

A synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH). Approved in Russia for stroke recovery, ADHD, and anxiety. Significant BDNF/NGF stimulation. Used off-label for cognitive enhancement and neuroprotection.

How it works

Increases brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) within minutes. Modulates dopamine, serotonin, and glutamate signaling. Crosses blood-brain barrier even at low doses.

What the research says

Russian clinical trials for stroke and cognitive disorders. Limited Western RCTs. Animal data robust on BDNF elevation and neuroprotection. Used widely in nootropic communities — anecdote-heavy.

Sources: PubMed: Semax

Common dosing ranges

Range: 300–600 mcg per dose; some protocols up to 1 mg
Frequency: Daily SubQ (NOT nasal — JD Denham); 1 month on / 1 week off
Duration: Cyclical only — receptors habituate

Sources: PubMed

Administration

SubQ · Nasal

Half-life

Short (minutes plasma; effects last hours via receptor activation)

Side effects

Common

Generally well-tolerated
Mild stimulation

Serious / theoretical

Long-term safety in healthy users not established
Theoretical: receptor desensitization with continuous use

Sources: PubMed

Notes

Pair with Selank as PM counterpart for calm + focus balance (Jacob Nachinson protocol). Bachmeyer uses it specifically for Alzheimer's/Parkinson's prevention. JD Denham insists on SubQ over nasal for systemic effect.