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FDA-approved·GLP-1 agonist

Semaglutide

aka Ozempic, Wegovy, Rybelsus

Education only. Many compounds discussed are research chemicals not approved for human use in the US. This is not medical advice — consult a licensed physician.

What it is

FDA-approved GLP-1 receptor agonist. Ozempic for type 2 diabetes, Wegovy for chronic weight management, Rybelsus for oral T2D.

How it works

Activates GLP-1 receptors to suppress appetite, slow gastric emptying, and enhance glucose-dependent insulin secretion.

What the research says

STEP trials showed ~15% weight loss at 68 weeks at 2.4mg/week.

Sources: STEP-1 NEJM · FDA Wegovy label

Common dosing ranges

Range
Start 0.25 mg/week, titrate to 2.4 mg/week
Frequency
Once weekly (subQ); daily for oral form
Duration
Long-term per FDA label

Sources: FDA label

Administration

SubQ · Oral

Half-life

~7 days

Side effects

Common

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation

Serious / theoretical

  • Pancreatitis
  • Gallbladder disease
  • Thyroid C-cell tumor warning

Sources: FDA label