Research only·Mitochondrial-derived peptide
MOTS-c
Education only. Many compounds discussed are research chemicals not approved for human use in the US. This is not medical advice — consult a licensed physician.
What it is
16-amino-acid peptide encoded in mitochondrial DNA. Studied for metabolic regulation, exercise mimicking, and insulin sensitivity. No FDA approval.
How it works
Activates AMPK pathway, regulates glucose homeostasis, and mimics some exercise-induced metabolic adaptations in animal models.
What the research says
Animal studies (Lee 2015) demonstrated improved insulin sensitivity. Human studies very limited.
Sources: Cell Metab Lee 2015
Common dosing ranges
- Range
- 5–10 mg per dose (anecdotal)
- Frequency
- 2–3× weekly
- Duration
- 4–8 week cycles
Sources: PubMed
Administration
SubQ
Half-life
~hours (estimated)